Chronic inflammation: The enemy within

The enemy within

When scientists start grumbling — and we do grumble a lot — much breath gets spent on how competitive science has become. Some of this is plainly nostalgia for a non-existent time when science was pure, everyone was funded, and there was plenty of time to dabble or to think. Even allowing for nostalgia, though, it does seem that the pressure of competition is growing yearly. Scientists spend mo...

The enemy within.

Death by transposition – the enemy within?

Here we present and develop the hypothesis that the derepression of endogenous retrotransposable elements (RTEs) - "genomic parasites" - is an important and hitherto under-unexplored molecular aging process that can potentially occur in most tissues. We further envision that the activation and continued presence of retrotransposition contribute to age-associated tissue degeneration and patholog...

a quick look at obesity; the enemy within

obesity with an increasing prevalence rate worldwide is correlated with multiple comorbidities. unfortunately, the currently available therapies such as the pharmacotherapy, bariatric surgery or gene-transfer technology are associated with a number of disadvantages including undesirable side effects, poor compliance or transient effectiveness. therefore, modifications of the lifestyle factors m...

Bioactive Lipids and Chronic Inflammation: Managing the Fire Within

Inflammation is an immune response that works as a contained fire that is pre-emptively sparked as a defensive process during infections or upon any kind of tissue insult, and that is spontaneously extinguished after elimination or termination of the damage. However, persistent and uncontrolled immune reactions act as a wildfire that promote chronic inflammation, unresolved tissue damage and, e...